Reactome | EPS15 and HGS bind ubiquitinated MET

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EPS15 and HGS bind ubiquitinated MET Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10537366
displayName	EPS15 and HGS bind ubiquitinated MET
eventOf	[Pathway:R-SSC-6807004] Negative regulation of MET activity - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8875490] EPS15 and HGS bind ubiquitinated MET - Homo sapiens
input	[Complex:R-SSC-182947] EPS15:HGS:STAM [cytosol] [CandidateSet:R-SSC-8875497] HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	EPS15 and HGS bind ubiquitinated MET
output	[Complex:R-SSC-8875489] HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane]
precedingEvent	[Reaction:R-SSC-8875482] CBL recruits CIN85:endophilin to ubiquitinated MET - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8875490
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6807004] Negative regulation of MET activity
(inferredTo)	[Reaction:R-HSA-8875490] EPS15 and HGS bind ubiquitinated MET