Reactome | Negative regulation of MET activity

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Negative regulation of MET activity Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558477
displayName	Negative regulation of MET activity
eventOf	[Pathway:R-SSC-6806834] Signaling by MET - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-6807027] PTPN1 and PTPN2 dephosphorylate MET - Sus scrofa [Reaction:R-SSC-8874685] CBL binds MET - Sus scrofa [Reaction:R-SSC-8875451] MET phosphorylates CBL - Sus scrofa [Reaction:R-SSC-8875183] CBL monoubiquitinates activated MET - Sus scrofa [Reaction:R-SSC-8875482] CBL recruits CIN85:endophilin to ubiquitinated MET - Sus scrofa [Reaction:R-SSC-8875374] MET binds LRIG1 - Sus scrofa [Reaction:R-SSC-8875443] USP8 deubiquitinates LRIG1 - Sus scrofa [Reaction:R-SSC-8875490] EPS15 and HGS bind ubiquitinated MET - Sus scrofa [Pathway:R-SSC-9734091] Drug-mediated inhibition of MET activation - Sus scrofa
inferredFrom	[Pathway:R-HSA-6807004] Negative regulation of MET activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Negative regulation of MET activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-6807004
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6806834] Signaling by MET
(inferredTo)	[Pathway:R-HSA-6807004] Negative regulation of MET activity

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