Reactome | p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11

Schema > Reaction > Entries

p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10534641
displayName	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
eventOf	[Pathway:R-SSC-8853659] RET signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Homo sapiens
input	[Complex:R-SSC-8855302] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-162563] PTPN11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
output	[Complex:R-SSC-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8855508
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8853659] RET signaling
(inferredTo)	[Reaction:R-HSA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11

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