Reactome | 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] - Sus scrofa
consumedByEvent	[BlackBoxEvent:R-SSC-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Sus scrofa [Reaction:R-SSC-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10534275
displayName	2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane]
hasComponent	[DefinedSet:R-SSC-8854907] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] [DefinedSet:R-SSC-8855296] p-5Y-GAB1,p-5Y-GAB2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8855302] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] - Homo sapiens
maxDepth	10
name	2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2
producedByEvent	[BlackBoxEvent:R-SSC-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-8855302
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-SSC-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K [Reaction:R-SSC-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
(hasComponent)	[Complex:R-SSC-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-SSC-8855762] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane]
(output)	[BlackBoxEvent:R-SSC-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated
(inferredTo)	[Complex:R-HSA-8855302] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane]

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