Reactome | Branched-chain amino acid catabolism

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Branched-chain amino acid catabolism Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10555699
displayName	Branched-chain amino acid catabolism
eventOf	[Pathway:R-SSC-71291] Metabolism of amino acids and derivatives - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19354] branched-chain amino acid catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] - Sus scrofa [Reaction:R-SSC-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Sus scrofa [Reaction:R-SSC-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Sus scrofa [Reaction:R-SSC-508179] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] - Sus scrofa [Pathway:R-SSC-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Sus scrofa [Reaction:R-SSC-5693148] BCKDK phosphorylates BCKDH - Sus scrofa [Reaction:R-SSC-9971123] CRAT transfers ISB to CAR - Sus scrofa [Reaction:R-SSC-9971621] GLYAT transfers ISB to glycine - Sus scrofa [Reaction:R-SSC-5693153] PPM1K dephosphorylates p-BCKDH - Sus scrofa [Reaction:R-SSC-70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 - Sus scrofa [Reaction:R-SSC-70773] beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA) - Sus scrofa [Reaction:R-SSC-508308] beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA) - Sus scrofa [Reaction:R-SSC-70785] beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA - Sus scrofa [Reaction:R-SSC-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Sus scrofa [Reaction:R-SSC-70837] alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ - Sus scrofa [Reaction:R-SSC-508369] alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ - Sus scrofa [Reaction:R-SSC-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Sus scrofa [Reaction:R-SSC-70859] isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 - Sus scrofa [Reaction:R-SSC-70870] ECHS1 hydrates methacrylyl-CoA - Sus scrofa [Reaction:R-SSC-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA - Sus scrofa [Reaction:R-SSC-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Sus scrofa [Reaction:R-SSC-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Sus scrofa [Reaction:R-SSC-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Sus scrofa
inferredFrom	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Branched-chain amino acid catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-70895
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-71291] Metabolism of amino acids and derivatives
(hasEncapsulatedEvent)	[Pathway:R-SSC-9857492] Protein lipoylation
(inferredTo)	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism

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