Reactome | Negative regulation of MET activity

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Negative regulation of MET activity Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created	[InstanceEdit:6807003] Orlic-Milacic, Marija, 2015-10-28
dbId	6807004
displayName	Negative regulation of MET activity
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806834] Signaling by MET - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6807008] PTPRJ dephosphorylates MET - Homo sapiens [Reaction:R-HSA-6807027] PTPN1 and PTPN2 dephosphorylate MET - Homo sapiens [Reaction:R-HSA-8874685] CBL binds MET - Homo sapiens [Reaction:R-HSA-8875451] MET phosphorylates CBL - Homo sapiens [Reaction:R-HSA-8875183] CBL monoubiquitinates activated MET - Homo sapiens [Reaction:R-HSA-8875482] CBL recruits CIN85:endophilin to ubiquitinated MET - Homo sapiens [Reaction:R-HSA-8875374] MET binds LRIG1 - Homo sapiens [Reaction:R-HSA-8875431] LRIG1 undergoes ubiquitination - Homo sapiens [Reaction:R-HSA-8875443] USP8 deubiquitinates LRIG1 - Homo sapiens [Reaction:R-HSA-8875490] EPS15 and HGS bind ubiquitinated MET - Homo sapiens [Pathway:R-HSA-9734091] Drug-mediated inhibition of MET activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:6807007] Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1 [LiteratureReference:6807026] Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase [LiteratureReference:8875449] The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met [LiteratureReference:8875387] Cbl-independent degradation of Met: ways to avoid agonism of bivalent Met-targeting antibody [LiteratureReference:8875397] USP8 modulates ubiquitination of LRIG1 for Met degradation [LiteratureReference:8851845] MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met [LiteratureReference:8851869] A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling [LiteratureReference:8874693] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein [LiteratureReference:8931776] Down-regulation of MET, the receptor for hepatocyte growth factor [LiteratureReference:8931927] Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Negative regulation of MET activity
orthologousEvent	[Pathway:R-CEL-6807004] Negative regulation of MET activity - Caenorhabditis elegans [Pathway:R-GGA-6807004] Negative regulation of MET activity - Gallus gallus [Pathway:R-XTR-6807004] Negative regulation of MET activity - Xenopus tropicalis [Pathway:R-DRE-6807004] Negative regulation of MET activity - Danio rerio [Pathway:R-SSC-6807004] Negative regulation of MET activity - Sus scrofa [Pathway:R-BTA-6807004] Negative regulation of MET activity - Bos taurus [Pathway:R-CFA-6807004] Negative regulation of MET activity - Canis familiaris [Pathway:R-RNO-6807004] Negative regulation of MET activity - Rattus norvegicus [Pathway:R-MMU-6807004] Negative regulation of MET activity - Mus musculus
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6807004
summation	[Summation:8875940] Signaling by MET receptor is negatively regulated mainly by ...
updateTrackers	[UpdateTracker:9778512] Update Tracker - [Pathway:6807004] Negative regulation of MET activity - v68:[updateContainedRLE] [UpdateTracker:9775903] Update Tracker - [Pathway:6807004] Negative regulation of MET activity - v78:[addHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9778512] Update Tracker - [Pathway:6807004] Negative regulation of MET activity - v68:[updateContainedRLE] [UpdateTracker:9775903] Update Tracker - [Pathway:6807004] Negative regulation of MET activity - v78:[addHasEvent]
(hasEvent)	[Pathway:R-HSA-6806834] Signaling by MET

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