Reactome | HPN heterodimer cleaves pro-HGF to form HGF dimer

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HPN heterodimer cleaves pro-HGF to form HGF dimer Show undefined attributes

catalystActivity	[CatalystActivity:10528814] serine-type endopeptidase activity of HPN heterodimer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10528831
displayName	HPN heterodimer cleaves pro-HGF to form HGF dimer
eventOf	[Pathway:R-SSC-6806942] MET Receptor Activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-6800298] HGF dimer binds MET - Sus scrofa
inferredFrom	[Reaction:R-HSA-6800200] HPN heterodimer cleaves pro-HGF to form HGF dimer - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [EntityWithAccessionedSequence:R-SSC-6800218] HGF [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	HPN heterodimer cleaves pro-HGF to form HGF dimer
output	[Complex:R-SSC-141763] HGF dimer [extracellular region]
regulatedBy	[NegativeRegulation:10528827] Negative regulation by 'SPINT1,2 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-6800200
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6806942] MET Receptor Activation
(precedingEvent)	[Reaction:R-SSC-6800298] HGF dimer binds MET
(inferredTo)	[Reaction:R-HSA-6800200] HPN heterodimer cleaves pro-HGF to form HGF dimer

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