Reactome | Recruitment of POLB to oxidatively damaged AP site

Schema > Reaction > Entries

Recruitment of POLB to oxidatively damaged AP site Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10516732
displayName	Recruitment of POLB to oxidatively damaged AP site
eventOf	[Pathway:R-SSC-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Sus scrofa
inferredFrom	[Reaction:R-HSA-5649854] Recruitment of POLB to oxidatively damaged AP site - Homo sapiens
input	[Complex:R-SSC-5649859] APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-53845] POLB [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of POLB to oxidatively damaged AP site
output	[Complex:R-SSC-5649858] POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-SSC-5649856] Oxidative damage to the AP site - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5649854
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway
(precedingEvent)	[Reaction:R-SSC-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
(inferredTo)	[Reaction:R-HSA-5649854] Recruitment of POLB to oxidatively damaged AP site

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