Reactome | POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site

Schema > Reaction > Entries

POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site Show undefined attributes

catalystActivity	[CatalystActivity:10454556] DNA-directed DNA polymerase activity of POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10454558
displayName	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
eventOf	[Pathway:R-SSC-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-SSC-5651801] PCNA-Dependent Long Patch Base Excision Repair - Sus scrofa [Reaction:R-SSC-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 - Sus scrofa [Reaction:R-SSC-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Sus scrofa
inferredFrom	[Reaction:R-HSA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-SSC-5649858] POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
output	[Complex:R-SSC-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-SSC-5649854] Recruitment of POLB to oxidatively damaged AP site - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-111253
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway
(precedingEvent)	[Pathway:R-SSC-5651801] PCNA-Dependent Long Patch Base Excision Repair [Reaction:R-SSC-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 [Reaction:R-SSC-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
(inferredTo)	[Reaction:R-HSA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site