Reactome | Recruitment of POLB to oxidatively damaged AP site

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Recruitment of POLB to oxidatively damaged AP site Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649855] Orlic-Milacic, Marija, 2014-11-21
dbId	5649854
displayName	Recruitment of POLB to oxidatively damaged AP site
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Homo sapiens
input	[Complex:R-HSA-5649859] APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-53845] POLB [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. [LiteratureReference:111248] Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). [LiteratureReference:5649853] Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Recruitment of POLB to oxidatively damaged AP site
orthologousEvent	[Reaction:R-DDI-5649854] Recruitment of POLB to oxidatively damaged AP site - Dictyostelium discoideum [Reaction:R-XTR-5649854] Recruitment of POLB to oxidatively damaged AP site - Xenopus tropicalis [Reaction:R-DRE-5649854] Recruitment of POLB to oxidatively damaged AP site - Danio rerio [Reaction:R-SSC-5649854] Recruitment of POLB to oxidatively damaged AP site - Sus scrofa [Reaction:R-BTA-5649854] Recruitment of POLB to oxidatively damaged AP site - Bos taurus [Reaction:R-CFA-5649854] Recruitment of POLB to oxidatively damaged AP site - Canis familiaris [Reaction:R-RNO-5649854] Recruitment of POLB to oxidatively damaged AP site - Rattus norvegicus [Reaction:R-MMU-5649854] Recruitment of POLB to oxidatively damaged AP site - Mus musculus
output	[Complex:R-HSA-5649858] POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5649856] Oxidative damage to the AP site - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5649854
summation	[Summation:5649860] APEX1 (APE1) bound to oxidatively damaged 5' AP (apurinic/ap...

Referrals

(hasEvent)	[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway
(precedingEvent)	[Reaction:R-HSA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site