Reactome | GRK1,4,7 phosphorylate MII to p-MII

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GRK1,4,7 phosphorylate MII to p-MII Show undefined attributes

catalystActivity	[CatalystActivity:10504915] rhodopsin kinase activity of GRK1,4,7 [photoreceptor disc membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:2514888] photoreceptor disc membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10504923
displayName	GRK1,4,7 phosphorylate MII to p-MII
eventOf	[Pathway:R-SSC-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2581474] GRK1,4,7 phosphorylate MII to p-MII - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-5205901] at-retinyl-RHO [photoreceptor disc membrane] 3 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GRK1,4,7 phosphorylate MII to p-MII GRK1 phosphorylates MII to p-S334,S338,S343-MII
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-SSC-5205903] phospho-p-S334,338,343-at-retinyl-RHO [photoreceptor disc membrane]
precedingEvent	[Reaction:R-SSC-74101] Photons induce isomerization of 11c-retinyl to at-retinyl - Sus scrofa
regulatedBy	[NegativeRegulation:10504924] Negative regulation by 'S-farn-GRK1:RCVRN:Ca2+ [photoreceptor disc membrane]' [NegativeRegulation:R-HSA-2730672] Negative regulation by 'Ca2+ [cytosol]' [NegativeRegulation:10451906] Negative regulation by 'p-MII:SAG [photoreceptor disc membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2581474
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2514859] Inactivation, recovery and regulation of the phototransduction cascade
(inferredTo)	[Reaction:R-HSA-2581474] GRK1,4,7 phosphorylate MII to p-MII