Reactome | An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3

Schema > Reaction > Entries

An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 Show undefined attributes

category	binding
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459964
displayName	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
eventOf	[Pathway:R-SSC-2173789] TGF-beta receptor signaling activates SMADs - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-170868] Activated type I receptor phosphorylates SMAD2/3 directly - Sus scrofa
inferredFrom	[Reaction:R-HSA-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-170855] SMAD3 [cytosol] [Complex:R-SSC-170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-206180] ZFYVE9 [early endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
output	[Complex:R-SSC-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
precedingEvent	[Reaction:R-SSC-170843] TGFBR2 phosphorylates TGFBR1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-170835
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2173789] TGF-beta receptor signaling activates SMADs
(precedingEvent)	[Reaction:R-SSC-170868] Activated type I receptor phosphorylates SMAD2/3 directly
(inferredTo)	[Reaction:R-HSA-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3

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