Reactome | Caspase 3-mediated cleavage of DFF45 (117)

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Caspase 3-mediated cleavage of DFF45 (117) Show undefined attributes

catalystActivity	[CatalystActivity:10469078] cysteine-type endopeptidase activity of active caspase-3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10469086
displayName	Caspase 3-mediated cleavage of DFF45 (117)
eventOf	[Pathway:R-SSC-140342] Apoptosis induced DNA fragmentation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-211186] Cleavage of DFF45 (224) by caspase-3 - Sus scrofa
inferredFrom	[Reaction:R-HSA-211190] Caspase 3-mediated cleavage of DFF45 (117) - Homo sapiens
input	[Complex:R-SSC-211225] DFFA:DFFB [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Caspase 3-mediated cleavage of DFF45 (117)
output	[Complex:R-SSC-211208] Caspase cleaved DFFA (117) [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-SSC-9029667] DFF dissociates from importin-alpha:importin-beta - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-211190
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-140342] Apoptosis induced DNA fragmentation
(precedingEvent)	[Reaction:R-SSC-211186] Cleavage of DFF45 (224) by caspase-3
(inferredTo)	[Reaction:R-HSA-211190] Caspase 3-mediated cleavage of DFF45 (117)

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