Reactome | Caspase 3-mediated cleavage of DFF45 (117)

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Caspase 3-mediated cleavage of DFF45 (117) Show undefined attributes

authored	[InstanceEdit:211183] Matthews, L, 2008-01-29 12:03:24
catalystActivity	[CatalystActivity:211202] cysteine-type endopeptidase activity of active caspase-3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:211216] Matthews, L, 2008-01-29 12:04:16
dbId	211190
displayName	Caspase 3-mediated cleavage of DFF45 (117)
edited	[InstanceEdit:212495] Matthews, L, 2008-02-12 15:38:34 [InstanceEdit:266293] Matthews, L, 2008-05-02 11:33:14
eventOf	[Pathway:R-HSA-140342] Apoptosis induced DNA fragmentation - Homo sapiens
followingEvent	[Reaction:R-HSA-211186] Cleavage of DFF45 (224) by caspase-3 - Homo sapiens
input	[Complex:R-HSA-211225] DFFA:DFFB [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:211226] DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase 3-mediated cleavage of DFF45 (117)
orthologousEvent	[Reaction:R-DME-211190] Caspase 3-mediated cleavage of DFF45 (117) - Drosophila melanogaster [Reaction:R-GGA-211190] Caspase 3-mediated cleavage of DFF45 (117) - Gallus gallus [Reaction:R-XTR-211190] Caspase 3-mediated cleavage of DFF45 (117) - Xenopus tropicalis [Reaction:R-DRE-211190] Caspase 3-mediated cleavage of DFF45 (117) - Danio rerio [Reaction:R-SSC-211190] Caspase 3-mediated cleavage of DFF45 (117) - Sus scrofa [Reaction:R-BTA-211190] Caspase 3-mediated cleavage of DFF45 (117) - Bos taurus [Reaction:R-CFA-211190] Caspase 3-mediated cleavage of DFF45 (117) - Canis familiaris [Reaction:R-RNO-211190] Caspase 3-mediated cleavage of DFF45 (117) - Rattus norvegicus [Reaction:R-MMU-211190] Caspase 3-mediated cleavage of DFF45 (117) - Mus musculus
output	[Complex:R-HSA-211208] Caspase cleaved DFFA (117) [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9029667] DFF dissociates from importin-alpha:importin-beta - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:349495] Widlak, P, 2008-05-07 23:54:18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-211190
summation	[Summation:211220] Caspase-3 cleaves the DFF45 subunit of the DFF45:DFF40 compl...
updateTrackers	[UpdateTracker:9787033] Update Tracker - [Reaction:211190] Caspase 3-mediated cleavage of DFF45 (117) - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787033] Update Tracker - [Reaction:211190] Caspase 3-mediated cleavage of DFF45 (117) - v46:[modifyText]
(hasEvent)	[Pathway:R-HSA-140342] Apoptosis induced DNA fragmentation
(precedingEvent)	[Reaction:R-HSA-211186] Cleavage of DFF45 (224) by caspase-3