Reactome | Apoptosis induced DNA fragmentation

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Apoptosis induced DNA fragmentation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556983
displayName	Apoptosis induced DNA fragmentation
eventOf	[Pathway:R-SSC-75153] Apoptotic execution phase - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:139817] apoptotic DNA fragmentation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-211224] Association of DFF40 with DFF45 - Sus scrofa [Reaction:R-SSC-211191] Association of DFF with alpha:beta importin - Sus scrofa [Reaction:R-SSC-211206] Translocation of DFF to the nucleus - Sus scrofa [BlackBoxEvent:R-SSC-9029667] DFF dissociates from importin-alpha:importin-beta - Sus scrofa [Reaction:R-SSC-211219] Translocation of caspase-3 to the nucleus - Sus scrofa [Reaction:R-SSC-211190] Caspase 3-mediated cleavage of DFF45 (117) - Sus scrofa [Reaction:R-SSC-211186] Cleavage of DFF45 (224) by caspase-3 - Sus scrofa [Reaction:R-SSC-211207] Cleaved fragments of DFF45 dissociate from DFF40 - Sus scrofa [Reaction:R-SSC-211193] Homodimerization of DFF40 - Sus scrofa [Reaction:R-SSC-211239] Association of DFF40 with chromatin - Sus scrofa [Reaction:R-SSC-266204] Association of HMGB1/HMGB2 with chromatin - Sus scrofa [Reaction:R-SSC-211247] Cleavage of DNA by DFF40 - Sus scrofa
inferredFrom	[Pathway:R-HSA-140342] Apoptosis induced DNA fragmentation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Apoptosis induced DNA fragmentation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-140342
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-75153] Apoptotic execution phase
(inferredTo)	[Pathway:R-HSA-140342] Apoptosis induced DNA fragmentation