Reactome | FGFR1c binds to Klotho-bound FGF23

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FGFR1c binds to Klotho-bound FGF23 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463077
displayName	FGFR1c binds to Klotho-bound FGF23
eventOf	[Pathway:R-SSC-190374] FGFR1c and Klotho ligand binding and activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c - Sus scrofa
inferredFrom	[Reaction:R-HSA-190268] FGFR1c binds to Klotho-bound FGF23 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-SSC-189897] FGFR1c [plasma membrane] [SimpleEntity:R-ALL-190915] HS [extracellular region] 2 × [Complex:R-SSC-190208] Klotho bound to FGF23 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FGFR1c binds to Klotho-bound FGF23
output	[Complex:R-SSC-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
regulatedBy	[Requirement:R-HSA-190314] Requirement by 'HS [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-190268
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-190374] FGFR1c and Klotho ligand binding and activation
(precedingEvent)	[Reaction:R-SSC-191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c
(inferredTo)	[Reaction:R-HSA-190268] FGFR1c binds to Klotho-bound FGF23

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