Reactome | CBL ubiquitinates Sprouty

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CBL ubiquitinates Sprouty Show undefined attributes

catalystActivity	[CatalystActivity:10462431] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10462433
displayName	CBL ubiquitinates Sprouty
eventOf	[Pathway:R-SSC-182971] EGFR downregulation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-183051] CBL ubiquitinates Sprouty - Homo sapiens
input	[Complex:R-SSC-182935] EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] [DefinedSet:R-SSC-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL ubiquitinates Sprouty
output	[Complex:R-SSC-182939] EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-183051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-182971] EGFR downregulation
(inferredTo)	[Reaction:R-HSA-183051] CBL ubiquitinates Sprouty