Reactome | EGFR downregulation

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EGFR downregulation Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556667
displayName	EGFR downregulation
eventOf	[Pathway:R-SSC-177929] Signaling by EGFR - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8094] negative regulation of epidermal growth factor receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-183055] Binding of CBL to EGFR - Sus scrofa [Reaction:R-SSC-182969] Phosphorylation of CBL (EGFR:CBL) - Sus scrofa [Reaction:R-SSC-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Sus scrofa [Reaction:R-SSC-182993] Ubiquitination of stimulated EGFR (CBL) - Sus scrofa [Reaction:R-SSC-183052] CBL binds to GRB2 - Sus scrofa [Reaction:R-SSC-183067] Localization of CBL:GRB2 to the membrane - Sus scrofa [Reaction:R-SSC-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Sus scrofa [Reaction:R-SSC-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Sus scrofa [BlackBoxEvent:R-SSC-182988] Sprouty lures CBL away from EGFR - Sus scrofa [Reaction:R-SSC-183094] CDC42:GTP binds CBL:Beta-Pix - Sus scrofa [Reaction:R-SSC-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - Sus scrofa [Reaction:R-SSC-8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 - Sus scrofa [Reaction:R-SSC-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Sus scrofa [Reaction:R-SSC-182994] Assembly of EGFR complex in clathrin-coated vesicles - Sus scrofa [Reaction:R-SSC-183072] EGFR non-clathrin mediated endocytosis - Sus scrofa [Reaction:R-SSC-183051] CBL ubiquitinates Sprouty - Sus scrofa [Reaction:R-SSC-182986] CBL-mediated ubiquitination of CIN85 - Sus scrofa [Reaction:R-SSC-182990] Sprouty sequesters CBL away from active EGFR - Sus scrofa [Reaction:R-SSC-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Sus scrofa [Reaction:R-SSC-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Sus scrofa [Reaction:R-SSC-8867041] EGFR phosphorylates EPS15 - Sus scrofa [Reaction:R-SSC-8867047] PTPN3 dephosphorylates EPS15 - Sus scrofa
inferredFrom	[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	EGFR downregulation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-182971
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-177929] Signaling by EGFR
(inferredTo)	[Pathway:R-HSA-182971] EGFR downregulation

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