Reactome | CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

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CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix Show undefined attributes

catalystActivity	[CatalystActivity:10462453] ubiquitin-protein transferase activity of EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10462455
displayName	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
eventOf	[Pathway:R-SSC-182971] EGFR downregulation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Sus scrofa
inferredFrom	[Reaction:R-HSA-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Homo sapiens
input	[Complex:R-SSC-182932] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] 2 × [DefinedSet:R-SSC-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
output	[Complex:R-SSC-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] 2 × [Complex:R-SSC-182915] Ub-Beta-Pix:CDC42:GTP [cytosol]
precedingEvent	[Reaction:R-SSC-8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-183084
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-182971] EGFR downregulation
(inferredTo)	[Reaction:R-HSA-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
(precedingEvent)	[Reaction:R-SSC-183058] Phosphorylation of CBL (EGFR:GRB2:CBL)

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