Reactome | EIF2AK2 [cytosol]

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EIF2AK2 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-9836700] EIF2AK2:PKR inhibitors [cytosol] - Sus scrofa [Complex:R-SSC-9835338] p-TARBP2:EIF2AK2 [cytosol] - Sus scrofa [Complex:R-SSC-9836494] EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-9835443] STAT1,STAT3 binds PKR - Sus scrofa [Reaction:R-SSC-9835189] NCK1 binds PKR - Sus scrofa [Reaction:R-SSC-9835328] NPM binds PKR - Sus scrofa [Reaction:R-SSC-9836702] PKR inhibitors bind PKR - Sus scrofa [Reaction:R-SSC-9836500] IKK complex is activated by PKR - Sus scrofa [Reaction:R-SSC-9835944] ADAR1 binds PKR - Sus scrofa [Reaction:R-SSC-9835385] DUS2 binds PKR - Sus scrofa [Reaction:R-SSC-9836606] SPHK1 binds PKR - Sus scrofa [Reaction:R-SSC-9835454] DNAJC3 binds PKR - Sus scrofa [Reaction:R-SSC-9835121] Heparin binds PKR - Sus scrofa [Reaction:R-SSC-9835121] Heparin binds PKR - Sus scrofa [Reaction:R-SSC-9833777] PKR binds activating host RNA - Sus scrofa [Reaction:R-SSC-9833777] PKR binds activating host RNA - Sus scrofa [Reaction:R-SSC-9834807] ILF3 binds PKR - Sus scrofa [Reaction:R-SSC-9834807] ILF3 binds PKR - Sus scrofa [Reaction:R-SSC-9834821] p-PRKRA dimer binds PKR - Sus scrofa [Reaction:R-SSC-9834821] p-PRKRA dimer binds PKR - Sus scrofa [Reaction:R-SSC-9835358] p-TARBP2 binds PKR - Sus scrofa [Reaction:R-SSC-9835411] FA core complex:HSP70s binds PKR - Sus scrofa [BlackBoxEvent:R-SSC-9833973] ISGylation of PKR - Sus scrofa [BlackBoxEvent:R-SSC-9833973] ISGylation of PKR - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10489233
displayName	EIF2AK2 [cytosol]
endCoordinate	551
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-SSC-1169379] ISG15 targets [cytosol] - Sus scrofa
name	EIF2AK2 A0A287BKF1
referenceEntity	[ReferenceGeneProduct:uniprot:A0A287BKF1] UniProt:A0A287BKF1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-168699
startCoordinate	2

Referrals

(hasMember)	[CandidateSet:R-SSC-1169379] ISG15 targets [cytosol]
(input)	[Reaction:R-SSC-9835944] ADAR1 binds PKR [Reaction:R-SSC-9835385] DUS2 binds PKR [Reaction:R-SSC-9836606] SPHK1 binds PKR [Reaction:R-SSC-9835454] DNAJC3 binds PKR [Reaction:R-SSC-9835121] Heparin binds PKR [Reaction:R-SSC-9833777] PKR binds activating host RNA [Reaction:R-SSC-9835443] STAT1,STAT3 binds PKR [Reaction:R-SSC-9835189] NCK1 binds PKR [BlackBoxEvent:R-SSC-9833973] ISGylation of PKR [Reaction:R-SSC-9834807] ILF3 binds PKR [Reaction:R-SSC-9835328] NPM binds PKR [Reaction:R-SSC-9834821] p-PRKRA dimer binds PKR [Reaction:R-SSC-9836702] PKR inhibitors bind PKR [Reaction:R-SSC-9835358] p-TARBP2 binds PKR [Reaction:R-SSC-9835411] FA core complex:HSP70s binds PKR [Reaction:R-SSC-9836500] IKK complex is activated by PKR
(hasComponent)	[Complex:R-SSC-9835338] p-TARBP2:EIF2AK2 [cytosol] [Complex:R-SSC-9836700] EIF2AK2:PKR inhibitors [cytosol] [Complex:R-SSC-9835934] ADAR1 dimer:EIF2AK2 [cytosol] [Complex:R-SSC-9835465] DNAJC3:EIF2AK2 [cytosol] [Complex:R-SSC-9835379] DUS2:EIF2AK2 [cytosol] [Complex:R-SSC-9835191] EIF2AK2:NCK1 [cytosol] [Complex:R-SSC-9836608] EIF2AK2:p-SPHK1 [cytosol] [Complex:R-SSC-9835442] STAT1,STAT3:EIF2AK2 [cytosol] [Complex:R-SSC-9835320] NPM1:EIF2AK2 [cytosol] [Complex:R-SSC-9833725] EIF2AK2 dimer [cytosol] [Complex:R-SSC-9835398] FA Core Complex:HSP70s:EIF2AK2 [cytosol] [Complex:R-SSC-9836494] EIF2AK2:CHUK:IKBKB:IKBKG [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol]

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