Reactome | factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

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factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10455705] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10457243
displayName	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
eventOf	[Pathway:R-SSC-9769743] Amplification and propagation of coagulation cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) - Sus scrofa [Reaction:R-SSC-9657706] factor XIa binds APP(18-770) - Sus scrofa [Reaction:R-SSC-9655851] factor XIa binds SERPINE1 - Sus scrofa [Reaction:R-SSC-9653838] factor XIa binds SERPING1 - Sus scrofa [Reaction:R-SSC-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Sus scrofa
inferredFrom	[Reaction:R-HSA-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Homo sapiens
input	[Complex:R-SSC-158162] factor XI:GPIb-IX-V complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
output	[Complex:R-SSC-158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane]
precedingEvent	[Reaction:R-SSC-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Sus scrofa [Reaction:R-SSC-158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - Sus scrofa
regulatedBy	[NegativeRegulation:10455986] Negative regulation by 'Extracellular thrombin inactivating complexes [extracellular region]' [NegativeRegulation:10455987] Negative regulation by 'SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane]' [NegativeRegulation:10455988] Negative regulation by 'Factor IIa inhibitors:IIa [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-158419
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-SSC-9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) [Reaction:R-SSC-9657706] factor XIa binds APP(18-770) [Reaction:R-SSC-9655851] factor XIa binds SERPINE1 [Reaction:R-SSC-9653838] factor XIa binds SERPING1 [Reaction:R-SSC-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
(hasEvent)	[Pathway:R-SSC-9769743] Amplification and propagation of coagulation cascade
(inferredTo)	[Reaction:R-HSA-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

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