Reactome | factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

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factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10457211] serine-type endopeptidase activity of factor XIa:GPIb:GPIX:GPV complex [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10457213
displayName	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
eventOf	[Pathway:R-SSC-9769743] Amplification and propagation of coagulation cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-140886] F9 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) activation of factor IX (factor XIa catalyst)
output	[EntityWithAccessionedSequence:R-SSC-140897] F9 [extracellular region] [Complex:R-SSC-140896] factor IXa [extracellular region]
precedingEvent	[Reaction:R-SSC-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Sus scrofa [Reaction:R-SSC-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Sus scrofa [BlackBoxEvent:R-SSC-9670673] FIX is secreted - Sus scrofa
regulatedBy	[PositiveRegulation:R-HSA-158645] Positive regulation by 'Ca2+ [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-158333
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9769743] Amplification and propagation of coagulation cascade
(inferredTo)	[Reaction:R-HSA-158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

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