Reactome | prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

Schema > Reaction > Entries

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10324106] serine-type endopeptidase activity of FVa:FXa [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10324110
displayName	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
eventOf	[Pathway:R-SSC-140875] Common Pathway of Fibrin Clot Formation - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - Sus scrofa [Reaction:R-SSC-140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - Sus scrofa [Reaction:R-SSC-140791] activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin - Sus scrofa [Reaction:R-SSC-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Sus scrofa [Reaction:R-SSC-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Sus scrofa [Reaction:R-SSC-140696] factor V -> factor Va + factor V activation peptide - Sus scrofa
inferredFrom	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-140674] F2 [extracellular region]
isInDisease	false
isInferred	true
name	prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
output	[Complex:R-SSC-156786] activated thrombin (factor IIa) [extracellular region] [EntityWithAccessionedSequence:R-SSC-140786] F2 [extracellular region]
precedingEvent	[Reaction:R-SSC-140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - Sus scrofa
regulatedBy	[NegativeRegulation:10324111] Negative regulation by 'Va:Xa:Factor Xa inhibitors [plasma membrane]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-140664
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-140875] Common Pathway of Fibrin Clot Formation
(precedingEvent)	[Reaction:R-SSC-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides [Reaction:R-SSC-140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B [Reaction:R-SSC-140791] activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin [Reaction:R-SSC-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin [Reaction:R-SSC-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) [Reaction:R-SSC-140696] factor V -> factor Va + factor V activation peptide
(inferredTo)	[Reaction:R-HSA-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)