Reactome | EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-1306962] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10490851
displayName	EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
hasComponent	[Complex:R-SSC-179849] GRB2:GAB1 [cytosol] [CandidateSet:R-SSC-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Homo sapiens
maxDepth	5
name	EGF:p-EGFR:p-ERBB2:GRB2:GAB1
producedByEvent	[Reaction:R-SSC-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-1306958
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-SSC-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
(output)	[Reaction:R-SSC-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
(hasComponent)	[Complex:R-SSC-1306962] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane]
(inferredTo)	[Complex:R-HSA-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]

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