Reactome | Binding of GRB2:GAB1 to p-ERBB2:p-EGFR

Schema > Reaction > Entries

Binding of GRB2:GAB1 to p-ERBB2:p-EGFR Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10490860
displayName	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
eventOf	[Pathway:R-SSC-1963642] PI3K events in ERBB2 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Sus scrofa
inferredFrom	[Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - Homo sapiens
input	[Complex:R-SSC-179849] GRB2:GAB1 [cytosol] [CandidateSet:R-SSC-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
output	[Complex:R-SSC-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
precedingEvent	[Reaction:R-SSC-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Sus scrofa [Reaction:R-SSC-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1306963
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1963642] PI3K events in ERBB2 signaling
(precedingEvent)	[Reaction:R-SSC-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
(inferredTo)	[Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR