Reactome | EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]

Schema > Complex > Entries

EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-1306962] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Homo sapiens
created	[InstanceEdit:1306964] Orlic-Milacic, Marija, 2011-05-27
dbId	1306958
displayName	EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
hasComponent	[Complex:R-HSA-179849] GRB2:GAB1 [cytosol] [CandidateSet:R-HSA-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Mus musculus [Complex:R-RNO-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Canis familiaris [Complex:R-BTA-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Bos taurus [Complex:R-SSC-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Sus scrofa [Complex:R-XTR-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Gallus gallus [Complex:R-DME-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - Caenorhabditis elegans
isChimeric	false
maxDepth	5
modified	[InstanceEdit:2213009] Matthews, L, 2012-04-27
name	EGF:p-EGFR:p-ERBB2:GRB2:GAB1
producedByEvent	[Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1306958
updateTrackers	[UpdateTracker:9894691] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9872197] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9877271] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v44:[updateContainedComponent] [UpdateTracker:9873062] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v42:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9894691] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9872197] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9877271] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v44:[updateContainedComponent] [UpdateTracker:9873062] Update Tracker - [Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] - v42:[updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:9665451] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] [EntityFunctionalStatus:9664931] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
(output)	[Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
(input)	[Reaction:R-HSA-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
(hasComponent)	[Complex:R-HSA-1306962] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane]

© 2026 Reactome

Cite Us!