Reactome | OPLAH hydrolyses OPRO to L-Glu

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OPLAH hydrolyses OPRO to L-Glu Show undefined attributes

catalystActivity	[CatalystActivity:10490035] 5-oxoprolinase (ATP-hydrolyzing) activity of OPLAH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10490037
displayName	OPLAH hydrolyses OPRO to L-Glu
eventOf	[Pathway:R-SSC-174403] Glutathione synthesis and recycling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-174367] GCL ligates L-Glu to L-Cys - Sus scrofa
inferredFrom	[Reaction:R-HSA-1247935] OPLAH hydrolyses OPRO to L-Glu - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1247942] OPRO [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	OPLAH hydrolyses OPRO to L-Glu Cleavage of 5-oxoproline to form glutamate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SSC-1247922] GGCT transforms gGluCys to OPRO - Sus scrofa [Reaction:R-SSC-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1247935
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-174403] Glutathione synthesis and recycling
(inferredTo)	[Reaction:R-HSA-1247935] OPLAH hydrolyses OPRO to L-Glu
(precedingEvent)	[Reaction:R-SSC-174367] GCL ligates L-Glu to L-Cys

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