Reactome | GGCT transforms gGluCys to OPRO

Schema > Reaction > Entries

GGCT transforms gGluCys to OPRO Show undefined attributes

catalystActivity	[CatalystActivity:10490026] gamma-glutamylcyclotransferase activity of GGCT dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10490028
displayName	GGCT transforms gGluCys to OPRO
eventOf	[Pathway:R-SSC-174403] Glutathione synthesis and recycling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1247935] OPLAH hydrolyses OPRO to L-Glu - Sus scrofa
inferredFrom	[Reaction:R-HSA-1247922] GGCT transforms gGluCys to OPRO - Homo sapiens
input	[SimpleEntity:R-ALL-174393] gGluCys [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GGCT transforms gGluCys to OPRO Formation of 5-oxoproline from gamma-glutamylcysteine
output	[SimpleEntity:R-ALL-111707] L-Cys [cytosol] [SimpleEntity:R-ALL-1247942] OPRO [cytosol]
precedingEvent	[Reaction:R-SSC-174367] GCL ligates L-Glu to L-Cys - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1247922
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-174403] Glutathione synthesis and recycling
(precedingEvent)	[Reaction:R-SSC-1247935] OPLAH hydrolyses OPRO to L-Glu
(inferredTo)	[Reaction:R-HSA-1247922] GGCT transforms gGluCys to OPRO

Cite Us!