Reactome | Formation of the cap-binding eIF4F complex

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Formation of the cap-binding eIF4F complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11053541
displayName	Formation of the cap-binding eIF4F complex
eventOf	[Pathway:R-SPO-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-72631] Formation of the cap-binding eIF4F complex - Homo sapiens
input	[Complex:R-SPO-72576] eIF4A subunits complex [cytosol] [EntityWithAccessionedSequence:R-SPO-72578] tif452 [cytosol] [EntityWithAccessionedSequence:R-SPO-72584] tif471 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of the cap-binding eIF4F complex
output	[Complex:R-SPO-72587] eIF4F [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-72631
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
(inferredTo)	[Reaction:R-HSA-72631] Formation of the cap-binding eIF4F complex

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