Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

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Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11078413
displayName	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
eventOf	[Pathway:R-SPO-72737] Cap-dependent Translation Initiation - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SPO-72631] Formation of the cap-binding eIF4F complex - Schizosaccharomyces pombe [BlackBoxEvent:R-SPO-72647] Cap-bound mRNA is activated by helicases - Schizosaccharomyces pombe [Pathway:R-SPO-72649] Translation initiation complex formation - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-72662
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-72737] Cap-dependent Translation Initiation
(inferredTo)	[Pathway:R-HSA-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

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