Reactome | CFTR transports Cl- from cytosol to extracellular region

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CFTR transports Cl- from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:11067558] chloride transmembrane transporter activity of CFTR [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11067560
displayName	CFTR transports Cl- from cytosol to extracellular region
eventOf	[Pathway:R-SPO-382556] ABC-family protein mediated transport - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5678863] CFTR transports Cl- from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CFTR transports Cl- from cytosol to extracellular region
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-SPO-8866851] CFTR transits to the plasma membrane - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-5678863
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-382556] ABC-family protein mediated transport
(inferredTo)	[Reaction:R-HSA-5678863] CFTR transports Cl- from cytosol to extracellular region

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