Reactome | SENP1,2,5 proteolytically process SUMO1

Schema > Reaction > Entries

SENP1,2,5 proteolytically process SUMO1 Show undefined attributes

catalystActivity	[CatalystActivity:11064530] SUMO-specific endopeptidase activity of SENP1,2,5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11064532
displayName	SENP1,2,5 proteolytically process SUMO1
eventOf	[Pathway:R-SPO-3065679] SUMO is proteolytically processed - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-2990833] Conjugation of SUMO1 to UBA2:SAE1 - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-2990840] SENP1,2,5 proteolytically process SUMO1 - Homo sapiens
input	[DefinedSet:R-SPO-2990831-3] Homologues of SUMO1(2-101) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SENP1,2,5 proteolytically process SUMO1
output	[DefinedSet:R-SPO-877304-3] Homologues of SUMO1 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-2990840
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-3065679] SUMO is proteolytically processed
(precedingEvent)	[Reaction:R-SPO-2990833] Conjugation of SUMO1 to UBA2:SAE1
(inferredTo)	[Reaction:R-HSA-2990840] SENP1,2,5 proteolytically process SUMO1

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