Reactome | SENP1,2,5 proteolytically process SUMO1

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SENP1,2,5 proteolytically process SUMO1 Show undefined attributes

authored	[InstanceEdit:2984266] May, B, 2013-01-16
catalystActivity	[CatalystActivity:2990845] SUMO-specific endopeptidase activity of SENP1,2,5 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644146] SUMO-specific endopeptidase activity of SENP1,2,5 [nucleoplasm] Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2990847] May, B, 2013-01-17
dbId	2990840
displayName	SENP1,2,5 proteolytically process SUMO1
edited	[InstanceEdit:2984266] May, B, 2013-01-16
eventOf	[Pathway:R-HSA-3065679] SUMO is proteolytically processed - Homo sapiens
followingEvent	[Reaction:R-HSA-2990833] Conjugation of SUMO1 to UBA2:SAE1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2990831] SUMO1(2-101) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3214960] Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1 [LiteratureReference:3214974] Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs [LiteratureReference:2984291] Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 [LiteratureReference:2984315] Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1 [LiteratureReference:2984289] Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex [LiteratureReference:3299587] Association of the human SUMO-1 protease SENP2 with the nuclear pore [LiteratureReference:3299590] Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SENP1,2,5 proteolytically process SUMO1
orthologousEvent	[Reaction:R-MMU-2990840] SENP1,2,5 proteolytically process SUMO1 - Mus musculus [Reaction:R-SCE-2990840] SENP1,2,5 proteolytically process SUMO1 - Saccharomyces cerevisiae [Reaction:R-SPO-2990840] SENP1,2,5 proteolytically process SUMO1 - Schizosaccharomyces pombe [Reaction:R-DDI-2990840] SENP1,2,5 proteolytically process SUMO1 - Dictyostelium discoideum [Reaction:R-CEL-2990840] SENP1,2,5 proteolytically process SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-2990840] SENP1,2,5 proteolytically process SUMO1 - Gallus gallus [Reaction:R-DRE-2990840] SENP1,2,5 proteolytically process SUMO1 - Danio rerio [Reaction:R-SSC-2990840] SENP1,2,5 proteolytically process SUMO1 - Sus scrofa [Reaction:R-BTA-2990840] SENP1,2,5 proteolytically process SUMO1 - Bos taurus [Reaction:R-CFA-2990840] SENP1,2,5 proteolytically process SUMO1 - Canis familiaris [Reaction:R-RNO-2990840] SENP1,2,5 proteolytically process SUMO1 - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-877304] SUMO1 [nucleoplasm]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448698] Garg, Amit K, 2013-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2990840
summation	[Summation:3222556] The SUMO1 precursor has 4 extra residues at the C-terminus w...

Referrals

(hasEvent)	[Pathway:R-HSA-3065679] SUMO is proteolytically processed
(precedingEvent)	[Reaction:R-HSA-2990833] Conjugation of SUMO1 to UBA2:SAE1

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