Reactome | Conjugation of SUMO1 to UBA2:SAE1

Schema > Reaction > Entries

Conjugation of SUMO1 to UBA2:SAE1 Show undefined attributes

catalystActivity	[CatalystActivity:11064512] SUMO activating enzyme activity of UBA2:SAE1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11064514
displayName	Conjugation of SUMO1 to UBA2:SAE1
eventOf	[Pathway:R-SPO-3065676] SUMO is conjugated to E1 (UBA2:SAE1) - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-2990833] Conjugation of SUMO1 to UBA2:SAE1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-SPO-877304-3] Homologues of SUMO1 [nucleoplasm] [Complex:R-SPO-2990843] UBA2:SAE1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Conjugation of SUMO1 to UBA2:SAE1
output	[SimpleEntity:R-ALL-164121] AMP [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [Complex:R-SPO-2993793] SUMO1:UBA2:SAE1 [nucleoplasm]
precedingEvent	[Reaction:R-SPO-2990840] SENP1,2,5 proteolytically process SUMO1 - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-2990833
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-3065676] SUMO is conjugated to E1 (UBA2:SAE1)
(precedingEvent)	[Reaction:R-SPO-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9)
(inferredTo)	[Reaction:R-HSA-2990833] Conjugation of SUMO1 to UBA2:SAE1