Reactome | PHLPP dephosphorylates S473 in AKT

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PHLPP dephosphorylates S473 in AKT Show undefined attributes

catalystActivity	[CatalystActivity:11058115] protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11058117
displayName	PHLPP dephosphorylates S473 in AKT
eventOf	[Pathway:R-SPO-199418] Negative regulation of the PI3K/AKT network - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferredFrom	[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [CandidateSet:R-SPO-202074] p-T,p-S-AKT [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PHLPP dephosphorylates S473 in AKT
output	[CandidateSet:R-SPO-202084] p-T-AKT [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-199425
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-199418] Negative regulation of the PI3K/AKT network
(inferredTo)	[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT

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