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Schema
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Reaction
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Entries
CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide
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authored
[InstanceEdit:9950028] May, Bruce, 2025-05-27
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9950017] May, Bruce, 2025-05-27
dbId
9950045
displayName
CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide
edited
[InstanceEdit:9950028] May, Bruce, 2025-05-27
input
[Complex:R-SCE-9950027] CDC48 hexamer [cytosol]
[Complex:R-SCE-9950599] NPL4:UFD1 [cytosol]
[Complex:R-SCE-9950044] RKR1:RQC1:RQC2:60S ribosomal subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala-Thr [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9948453] Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products
[LiteratureReference:9949896] A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
[LiteratureReference:9949893] Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
[LiteratureReference:9950026] In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome
[LiteratureReference:9950023] Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
[LiteratureReference:9950063] The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48
maxDepth
1
modified
[InstanceEdit:9971549] May, Bruce, 2025-11-07
name
CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide
orthologousEvent
[Reaction:R-HSA-9948415] VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide - Homo sapiens
output
[Complex:R-SCE-9950036] CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala-Thr [cytosol]
previousReviewStatus
[ReviewStatus:9821383] three stars
releaseDate
2025-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09
[InstanceEdit:9962794] Ford, Pierce W, 2025-08-09
[InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07
[InstanceEdit:9971510] McGirr, Tom, 2025-11-07
schemaClass
Reaction
species
[Species:68322] Saccharomyces cerevisiae
stId
R-SCE-9950045
summation
[Summation:9950591] A hexamer of CDC48 subunits and the NPL4:UFD1 heterodimer bi...
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