A hexamer of CDC48 subunits and the NPL4:UFD1 heterodimer bi...

created [InstanceEdit:9950587] May, Bruce, 2025-05-27
dbId 9950591
displayName A hexamer of CDC48 subunits and the NPL4:UFD1 heterodimer bi...
modified [InstanceEdit:9956849] May, Bruce, 2025-06-15
schemaClass Summation
text A hexamer of CDC48 subunits and the NPL4:UFD1 heterodimer bind polyubiquitin containing lysine-48 linkages (K48polyUb) conjugated to the nascent peptide emerging from the exit tunnel of the 60S ribosomal subunit (Brandman et al. 2012, Defenouillère et al. 2013, Verma et al. 2013). NPL4 (homolog of human NPLOC4) and UFD1 (homolog of human UFD1L) establish the selectivity of CDC48 binding to K48 polyubiquitin (Tsuchiya et al. 2017, Sato et al. 2019, Williams et al. 2023).
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