Reactome | CDC48 hexamer [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SCE-9950040] RKR1:RQC2:RQC1:CDC48 hexamer:K48polyUb-nascent peptide-Ala-Thr [cytosol] - Saccharomyces cerevisiae [Complex:R-SCE-9950036] CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala-Thr [cytosol] - Saccharomyces cerevisiae [Complex:R-SCE-9950019] CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:K48polyUb-nascent peptide-Ala-Thr [cytosol] - Saccharomyces cerevisiae
consumedByEvent	[Reaction:R-SCE-9950045] CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide - Saccharomyces cerevisiae
created	[InstanceEdit:9950017] May, Bruce, 2025-05-27
dbId	9950027
displayName	CDC48 hexamer [cytosol]
hasComponent	6 × [EntityWithAccessionedSequence:R-SCE-9950047] CDC48 [cytosol]
inDisease	false
isChimeric	false
maxDepth	2
name	CDC48 hexamer
producedByEvent	[BlackBoxEvent:R-SCE-9953094] The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer - Saccharomyces cerevisiae
schemaClass	Complex
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9950027

(output)	[BlackBoxEvent:R-SCE-9953094] The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer
(hasComponent)	[Complex:R-SCE-9950040] RKR1:RQC2:RQC1:CDC48 hexamer:K48polyUb-nascent peptide-Ala-Thr [cytosol] [Complex:R-SCE-9950019] CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:K48polyUb-nascent peptide-Ala-Thr [cytosol] [Complex:R-SCE-9950036] CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala-Thr [cytosol]
(activeUnit)	[CatalystActivity:9950589] ATP hydrolysis activity of CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:K48polyUb-nascent peptide-Ala-Thr [cytosol]
(input)	[Reaction:R-SCE-9950045] CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide

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