Reactome | CDT1-mediated loading of MCM2-7 to replication origin in budding yeast

Schema > Reaction > Entries

authored	[InstanceEdit:9757622] Kusic-Tisma, Jelena, 2021-10-27
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9749344] Orlic-Milacic, Marija, 2021-08-01
dbId	9749345
displayName	CDT1-mediated loading of MCM2-7 to replication origin in budding yeast
edited	[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
input	[Complex:R-SCE-9749307] yCDT1:yMCM2-7 [nucleoplasm] [Complex:R-SCE-9749327] yORC(1-6):yCDC6:origin of replication [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9749309] An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly [LiteratureReference:9749250] Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDT1-mediated loading of MCM2-7 to replication origin in budding yeast
orthologousEvent	[Reaction:R-HSA-9749320] CDT1-mediated loading of MCM2-7 to replication origins - Homo sapiens
output	[Complex:R-SCE-9749343] yORC(1-6):yCDC6:origin of replication:yCDT1:yMCM2-7 [nucleoplasm]
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9749345
summation	[Summation:9749346] Based on yeast studies, CDT1 binding to the MCM2-7 complex i...

Cite Us!