Reactome | CDT1-mediated loading of MCM2-7 to replication origins

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CDT1-mediated loading of MCM2-7 to replication origins Show undefined attributes

authored	[InstanceEdit:9757622] Kusic-Tisma, Jelena, 2021-10-27
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9749317] Orlic-Milacic, Marija, 2021-08-01
dbId	9749320
deleted	[Deleted:9768317] Deletion of instance: 68826
displayName	CDT1-mediated loading of MCM2-7 to replication origins
edited	[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
eventOf	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex - Homo sapiens
followingEvent	[Reaction:R-HSA-9749350] ATP-dependent release of CDT1 from the OCCM complex - Homo sapiens
inferredFrom	[Reaction:R-SCE-9749345] CDT1-mediated loading of MCM2-7 to replication origin in budding yeast - Saccharomyces cerevisiae
input	[Complex:R-HSA-9749283] CDT1:MCM2-7 [nucleoplasm] [Complex:R-HSA-9749216] ORC(1-6):CDC6:origin of replication [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9749277] Geminin inhibits a late step in the formation of human pre-replicative complexes [LiteratureReference:68713] Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDT1-mediated loading of MCM2-7 to replication origins
output	[Complex:R-HSA-9749318] ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9749286] CDT1 binds MCM2-7 - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9749320
summation	[Summation:9749342] While the simultaneous binding of CDT1 to the MCM2-7 complex...

Referrals

(replacementInstances)	[Deleted:9768317] Deletion of instance: 68826
(hasEvent)	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex
(precedingEvent)	[Reaction:R-HSA-9749350] ATP-dependent release of CDT1 from the OCCM complex
(inferredTo)	[Reaction:R-SCE-9749345] CDT1-mediated loading of MCM2-7 to replication origin in budding yeast

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