Reactome | GCN2 phosphorylates SUI2

Schema > Reaction > Entries

GCN2 phosphorylates SUI2 Show undefined attributes

authored	[InstanceEdit:9633461] May, Bruce, 2018-12-28
catalystActivity	[CatalystActivity:9633514] protein serine/threonine kinase activity of tRNA:p-T882,887-GCN2:GCN1:80S ribosome:mRNA [cytosol]
catalystActivityReference	[CatalystActivityReference:9644923] protein serine/threonine kinase activity of tRNA:p-T882,887-GCN2:GCN1:80S ribosome:mRNA [cytosol] A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9633466] May, Bruce, 2018-12-29
dbId	9633480
displayName	GCN2 phosphorylates SUI2
edited	[InstanceEdit:9633461] May, Bruce, 2018-12-28
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SCE-9633532] SUI2:SUI3:GCD11 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9635254] Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast [LiteratureReference:9633776] The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids [LiteratureReference:9635245] Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases [LiteratureReference:9635241] GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 [LiteratureReference:9635244] Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase [LiteratureReference:9633790] Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p [LiteratureReference:9633756] A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GCN2 phosphorylates SUI2
orthologousEvent	[Reaction:R-MMU-9633504] Eif2ak4 phosphorylates Eif2s1 - Mus musculus [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SCE-9633544] p-S52-SUI2:SUI3:GCD11 [cytosol]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9633480
summation	[Summation:9635247] GCN2 phosphorylates SUI2 (eIF-2 alpha subunit) on serine-52 ...

Cite Us!