Reactome | GCN2 phosphorylates SUI2

GCN2 phosphorylates SUI2

Stable Identifier

R-SCE-9633480

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

cytosol

ReviewStatus

5/5

General

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GCN2 phosphorylates SUI2 (eIF-2 alpha subunit) on serine-52 in response to amino acid starvation (serine-51 in the rabbit homolog, Dever et al. 1992, Ramirez et al. 1992, Marton et al. 1993, Wek et al. 1995, Yang et al. 2000, Garriz et al. 2009, Zaborske et al. 2009). GCN1 is required for phosphorylation of SUI2 by GCN2 (Marton et al. 1993). The phosphorylation affects reinitiation of translation and causes downregulation of translation of most mRNAs, however translation of certain mRNAs possessing upstream ORFs, such as GCN4, is upregulated (Dever et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
10733573	Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase Wek, SA, Wek, RC, Yang, R	Mol. Cell. Biol.	2000
19114556	A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2 Dey, M, Dever, TE, Qiu, H, Hinnebusch, AG, Seo, EJ, Gárriz, A	Mol. Cell. Biol.	2009
1448107	Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases Freeman, B, Ramirez, M, Hinnebusch, AG, Wek, RC, Vazquez de Aldana, CR, Jackson, BM	Mol. Cell. Biol.	1992
19546227	Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p Freimoser, F, Jiang, L, Dittmar, KA, Wek, RC, Zaborske, JM, Narasimhan, J, Pan, T, Wek, SA	J. Biol. Chem.	2009
8497269	GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 Hinnebusch, AG, Crouch, D, Marton, MJ	Mol. Cell. Biol.	1993
1739968	Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast Dever, TE, Donahue, TF, Hinnebusch, AG, Wek, RC, Cigan, AM, Feng, L	Cell	1992
7623840	The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids Wek, SA, Zhu, S, Wek, RC	Mol. Cell. Biol.	1995