Reactome | Eif2ak4 phosphorylates Eif2s1

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Eif2ak4 phosphorylates Eif2s1 Show undefined attributes

authored	[InstanceEdit:9633461] May, Bruce, 2018-12-28
catalystActivity	[CatalystActivity:9633515] protein serine/threonine kinase activity of tRNA:p-T898-Eif2ak4:Gcn1:80S ribosome:mRNA [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9633466] May, Bruce, 2018-12-29
dbId	9633504
displayName	Eif2ak4 phosphorylates Eif2s1
edited	[InstanceEdit:9633461] May, Bruce, 2018-12-28
inferredFrom	[Reaction:R-SCE-9633480] GCN2 phosphorylates SUI2 - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9633520] Eif2s1:Eif2s2:Eif2s3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9633858] A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha [LiteratureReference:9633880] Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Eif2ak4 phosphorylates Eif2s1
orthologousEvent	[Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-9633492] p-S52-Eif2s1:Eif2s2:Eif2s3 [cytosol]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9633504
summation	[Summation:9633868] After binding uncharged tRNA and autophosphorylating, Eif2ak...

Referrals

(inferredTo)

[Reaction:R-SCE-9633480] GCN2 phosphorylates SUI2

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