Reactome | DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2

Schema > Reaction > Entries

DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 Show undefined attributes

catalystActivity	[CatalystActivity:11095548] 2-(3-amino-3-carboxypropyl)histidine synthase activity of DPH1:DPH2:DPH3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11095550
displayName	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2
eventOf	[Pathway:R-SCE-5358493] Synthesis of diphthamide-EEF2 - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [EntityWithAccessionedSequence:R-SCE-5358472] nascent EEF2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2
output	[EntityWithAccessionedSequence:R-SCE-5358478] aminocarboxypropyl EEF2 [cytosol] [SimpleEntity:R-ALL-353106] MTAD [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-5358494
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-5358493] Synthesis of diphthamide-EEF2
(precedingEvent)	[Reaction:R-SCE-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2
(inferredTo)	[Reaction:R-HSA-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2

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