Reactome | Formation of translation initiation complexes containing mRNA that does not circularize

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Formation of translation initiation complexes containing mRNA that does not circularize Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11084707
displayName	Formation of translation initiation complexes containing mRNA that does not circularize
eventOf	[Pathway:R-SCE-72649] Translation initiation complex formation - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-72621] Ribosomal scanning - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Homo sapiens
input	[Complex:R-SCE-72571] 43S complex [cytosol] [Complex:R-SCE-72593] mRNA:eIF4F:eIF4B:eIF4H [cytosol] [EntityWithAccessionedSequence:R-SCE-72557] TIF11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of translation initiation complexes containing mRNA that does not circularize
output	[Complex:R-SCE-72594] 48S complex [cytosol] [EntityWithAccessionedSequence:R-SCE-72557] TIF11 [cytosol]
precedingEvent	[BlackBoxEvent:R-SCE-72647] Cap-bound mRNA is activated by helicases - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-157849
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-72649] Translation initiation complex formation
(precedingEvent)	[Reaction:R-SCE-72621] Ribosomal scanning
(inferredTo)	[Reaction:R-HSA-157849] Formation of translation initiation complexes containing mRNA that does not circularize

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