Reactome | Cap-bound mRNA is activated by helicases

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Cap-bound mRNA is activated by helicases Show undefined attributes

catalystActivity	[CatalystActivity:11082449] RNA helicase activity of eIF4A subunits complex [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11082451
displayName	Cap-bound mRNA is activated by helicases
eventOf	[Pathway:R-SCE-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-156808] Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation - Saccharomyces cerevisiae [Reaction:R-SCE-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Saccharomyces cerevisiae
inferredFrom	[BlackBoxEvent:R-HSA-72647] Cap-bound mRNA is activated by helicases - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SCE-72576] eIF4A subunits complex [cytosol] [Complex:R-SCE-72597] eIF4F:mRNP [cytosol] [DefinedSet:R-SCE-72589-3] Homologues of EIF4B [cytosol] [EntityWithAccessionedSequence:R-SCE-72591] TIF3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cap-bound mRNA is activated by helicases
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SCE-72576] eIF4A subunits complex [cytosol] [Complex:R-SCE-72593] mRNA:eIF4F:eIF4B:eIF4H [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [OtherEntity:R-ALL-72595] RNA-binding protein in RNP (ribonucleoprotein) complexes [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-72647
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
(precedingEvent)	[Reaction:R-SCE-156808] Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation [Reaction:R-SCE-157849] Formation of translation initiation complexes containing mRNA that does not circularize
(inferredTo)	[BlackBoxEvent:R-HSA-72647] Cap-bound mRNA is activated by helicases

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