Reactome | MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds

Schema > Reaction > Entries

MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds Show undefined attributes

authored	[InstanceEdit:1252263] May, B, 2011-04-22
catalystActivity	[CatalystActivity:1252256] protein-disulfide reductase activity of MIA40:ERV1 [mitochondrial intermembrane space]
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:1252251] May, B, 2011-04-27
dbId	1252260
deleted	[Deleted:9697205] Deletion of instance: 1252265
displayName	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds
edited	[InstanceEdit:1252263] May, B, 2011-04-22
input	[DefinedSet:R-SCE-1252222] Substrates of MIA40-ERV1 [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1252307] The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria [LiteratureReference:1254360] A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding [LiteratureReference:1254343] The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40 [LiteratureReference:1254332] Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione [LiteratureReference:1254354] Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins [LiteratureReference:1252330] Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase [LiteratureReference:1254367] Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space [LiteratureReference:1254342] Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions [LiteratureReference:1254339] Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria [LiteratureReference:1254368] Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40 [LiteratureReference:1254373] Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins [LiteratureReference:1254359] Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria [LiteratureReference:1254331] Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space [LiteratureReference:1254364] The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1 [LiteratureReference:1254346] The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway [LiteratureReference:1254357] Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway [LiteratureReference:1258379] Systematic analysis of the twin cx(9)c protein family [LiteratureReference:1307736] The disulfide relay system of mitochondria is connected to the respiratory chain [LiteratureReference:1307741] Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c [LiteratureReference:2127665] Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol [LiteratureReference:3779380] Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds
orthologousEvent	[Reaction:R-HSA-1307802] MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds - Homo sapiens
output	[DefinedSet:R-SCE-1252217] Products of MIA40-ERV1 [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-SCE-1252255] TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space - Saccharomyces cerevisiae
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1252260
summation	[Summation:1258359] MIA40 catalyzes the oxidation of cysteine residues in precur...
updateTrackers	[UpdateTracker:9787125] Update Tracker - [Reaction:1252260] MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds - v46:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9787125] Update Tracker - [Reaction:1252260] MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds - v46:[addLiteratureReference]
(replacementInstances)	[Deleted:9697205] Deletion of instance: 1252265

Cite Us!