Reactome | Products of MIA40-ERV1 [mitochondrial intermembrane space]

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Products of MIA40-ERV1 [mitochondrial intermembrane space] Show undefined attributes

compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:1252211] May, B, 2011-04-27
dbId	1252217
displayName	Products of MIA40-ERV1 [mitochondrial intermembrane space]
hasMember	[EntityWithAccessionedSequence:R-SCE-1252161] 4xHC-COX17 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252085] 4xHC-COX19 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252084] 4xHC-MDM35 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252073] 4xHC-MIC14 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252074] 4xHC-MIC17 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252053] 4xHC-TIM10 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252088] 4xHC-TIM13 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252071] 4xHC-TIM8 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252155] 4xHC-TIM9 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-2127671] 2xHC-CCS1 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-8874890] 4xHC-CMC2 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-8874885] 4xHC-COA4 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-8874922] 4xHC-CMC4 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-8874940] 4xHC-COA6 [mitochondrial intermembrane space] - Saccharomyces cerevisiae
inDisease	false
inferredTo	[CandidateSet:R-HSA-1307799] Products of MIA40:ERV1 [mitochondrial intermembrane space] - Homo sapiens
isOrdered	true
literatureReference	[LiteratureReference:1254360] A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding [LiteratureReference:1254368] Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40 [LiteratureReference:1254373] Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins [LiteratureReference:1254339] Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria [LiteratureReference:1254342] Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions [LiteratureReference:1254332] Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione [LiteratureReference:1254357] Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway [LiteratureReference:1254331] Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space [LiteratureReference:1254367] Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space [LiteratureReference:1254354] Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins [LiteratureReference:1254359] Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria [LiteratureReference:1254364] The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1 [LiteratureReference:1254346] The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway [LiteratureReference:1254343] The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40 [LiteratureReference:1252307] The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria [LiteratureReference:1252330] Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase [LiteratureReference:2127665] Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol [LiteratureReference:1258379] Systematic analysis of the twin cx(9)c protein family
maxDepth	2
modified	[InstanceEdit:8874959] May, Bruce, 2016-05-30
name	Products of MIA40-ERV1
producedByEvent	[Reaction:R-SCE-1252260] MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds - Saccharomyces cerevisiae
schemaClass	DefinedSet
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1252217
updateTrackers	[UpdateTracker:9894932] Update Tracker - [DefinedSet:1252217] Products of MIA40-ERV1 [mitochondrial intermembrane space] - v58:[addHasMember, addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9894932] Update Tracker - [DefinedSet:1252217] Products of MIA40-ERV1 [mitochondrial intermembrane space] - v58:[addHasMember, addLiteratureReference]
(output)	[Reaction:R-SCE-1252260] MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds

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