Reactome | MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds

MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds

Stable Identifier

R-SCE-1252260

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

mitochondrial intermembrane space

ReviewStatus

5/5

General

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MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds

MIA40 catalyzes the oxidation of cysteine residues in precursor proteins in the intermembrane space to form cystine bonds (Chacinska et al. 2004, Terziyska et al. 2005, Milenkovic 2007, Sideris and Tokatlidis 2007, Terziyska et al. 2007, Misecke et al. 2008, Muller et al. 2008, Milenkovic et al. 2009, Stojanovski et al. 2008, Longen et al. 2009, Milenkovic et al. 2009, Reddehase et al. 2009, Sideris et al. 2009, Terziyska et al. 2009, Tienson et al. 2009, Bien et al. 2010). The electrons from the cysteine residues are transferred to MIA40, then to ERV1, and eventually to the respiratory chain (Allen et al. 2005, Bihlmaier et al. 2007). The interaction between MIA40 and ERV1 appears to be transitory (Stojanovski et al. 2008). Substrates of MIA40:ERV1 include COX17 (Mesecke et al. 2008, Sideris et al. 2009), COX19 (Bien et al. 2010), CMC2 (Longen et al. 2009), CMC3 (Longen et al. 2009), CMC4 (Longen et al. 2009), TIM13 (Terziyska et al. 2005, Muller et al. 2008, Stojanovski et al. 2008), TIM9 (Chacinska et al. 2004, Milenkovic et al. 2007, Stojanovski et al. 2008, Milenkovic et al. 2009), TIM10 (Chacinska et al. 2004, Milenkovic et al. 2007, Sideris and Tokatlidis 2007, Stojanovski et al. 2008, Terziyska et al. 2009, Milenkovic et al. 2009), CCS1 (Stojanovski et al. 2008, Reddehase et al. 2009), TIM8 (Muller et al. 2008, Stojanovski et al. 2008), and ERV1 (Terziyska et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17336303	The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway Terziyska, N, Grumbt, B, Bien, M, Neupert, W, Herrmann, JM, Hell, K	FEBS Lett	2007
18852299	Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase Stojanovski, D, Milenkovic, D, Müller, JM, Gabriel, K, Schulze-Specking, A, Baker, MJ, Ryan, MT, Guiard, B, Pfanner, N, Chacinska, A	J Cell Biol	2008
19703468	Systematic analysis of the twin cx(9)c protein family Longen, S, Bien, M, Bihlmaier, K, Kloeppel, C, Kauff, F, Hammermeister, M, Westermann, B, Herrmann, JM, Riemer, J	J Mol Biol	2009
15359280	Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins Chacinska, A, Pfannschmidt, S, Wiedemann, N, Kozjak, V, Sanjuán Szklarz, LK, Schulze-Specking, A, Truscott, KN, Guiard, B, Meisinger, C, Pfanner, N	EMBO J	2004
15620710	Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions Terziyska, N, Lutz, T, Kozany, C, Mokranjac, D, Mesecke, N, Neupert, W, Herrmann, JM, Hell, K	FEBS Lett	2005
18787558	The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40 Mesecke, N, Bihlmaier, K, Grumbt, B, Longen, S, Terziyska, N, Hell, K, Herrmann, JM	EMBO Rep	2008
17553782	Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40 Milenkovic, D, Gabriel, K, Guiard, B, Schulze-Specking, A, Pfanner, N, Chacinska, A	J Biol Chem	2007
21865594	Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol Klöppel, C, Suzuki, Y, Kojer, K, Petrungaro, C, Longen, S, Fiedler, S, Keller, S, Riemer, J	Mol Biol Cell	2011
19297525	Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria Milenkovic, D, Ramming, T, Müller, JM, Wenz, LS, Gebert, N, Schulze-Specking, A, Stojanovski, D, Rospert, S, Chacinska, A	Mol Biol Cell	2009
19010334	The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1 Reddehase, S, Grumbt, B, Neupert, W, Hell, K	J Mol Biol	2009
20188670	Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione Bien, M, Longen, S, Wagener, N, Chwalla, I, Herrmann, JM, Riemer, J	Mol Cell	2010
16185707	Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c Allen, S, Balabanidou, V, Sideris, DP, Lisowsky, T, Tokatlidis, K	J Mol Biol	2005
21865601	Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system Gross, DP, Burgard, CA, Reddehase, S, Leitch, JM, Culotta, VC, Hell, K	Mol. Biol. Cell	2011
17978092	Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space Müller, JM, Milenkovic, D, Guiard, B, Pfanner, N, Chacinska, A	Mol Biol Cell	2008
17967948	The disulfide relay system of mitochondria is connected to the respiratory chain Bihlmaier, K, Mesecke, N, Terziyska, N, Bien, M, Hell, K, Herrmann, JM	J Cell Biol	2007
20026652	A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding Sideris, DP, Petrakis, N, Katrakili, N, Mikropoulou, D, Gallo, A, Ciofi-Baffoni, S, Banci, L, Bertini, I, Tokatlidis, K	J Cell Biol	2009
17680986	Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space Sideris, DP, Tokatlidis, K	Mol Microbiol	2007
17095012	Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway Gabriel, K, Milenkovic, D, Chacinska, A, Müller, J, Guiard, B, Pfanner, N, Meisinger, C	J Mol Biol	2007
19011240	Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria Terziyska, N, Grumbt, B, Kozany, C, Hell, K	J Biol Chem	2009
19477928	Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins Tienson, HL, Dabir, DV, Neal, SE, Loo, R, Hasson, SA, Boontheung, P, Kim, SK, Loo, JA, Koehler, CM	Mol Biol Cell	2009
20367271	The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria Lionaki, E, Aivaliotis, M, Pozidis, C, Tokatlidis, K	Antioxid Redox Signal	2010