Reactome | Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination

Schema > BlackBoxEvent > Entries

Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination Show undefined attributes

authored	[InstanceEdit:9958807] Adan, Hanad, 2025-05-25 [InstanceEdit:9958843] Daniel, Juliet, 2025-05-25 [InstanceEdit:9958824] Raptis, Leda, 2025-05-25
catalystActivity	[CatalystActivity:9959455] ubiquitin-protein transferase activity of RAC1,(CDC42) Ubiquitin Ligase [cytosol]
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9958870] Orlic-Milacic, Marija, 2025-06-25
dbId	9958873
displayName	Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
eventOf	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9958874] 26S proteasome degrades ubiquitinated RAC1, CDC42 - Homo sapiens
input	[CandidateSet:R-HSA-9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9967943] The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1 [LiteratureReference:9967991] Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation [LiteratureReference:9968011] The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation [LiteratureReference:9967963] Carbon-Ion Irradiation Suppresses Migration and Invasiveness of Human Pancreatic Carcinoma Cells MIAPaCa-2 via Rac1 and RhoA Degradation [LiteratureReference:9967971] The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling [LiteratureReference:9967967] Ubiquitin-dependent regulation of Cdc42 by XIAP [LiteratureReference:9968020] Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development [LiteratureReference:9967977] IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation [LiteratureReference:9968027] Ubiquitination of Rac1 by inhibitors of apoptosis (IAPs) [LiteratureReference:9967973] DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination
orthologousEvent	[BlackBoxEvent:R-SSC-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Sus scrofa [BlackBoxEvent:R-DME-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Drosophila melanogaster [BlackBoxEvent:R-GGA-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Gallus gallus [BlackBoxEvent:R-DRE-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Danio rerio [BlackBoxEvent:R-CFA-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Canis familiaris [BlackBoxEvent:R-RNO-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Rattus norvegicus [BlackBoxEvent:R-MMU-9958873] Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination - Mus musculus
output	[CandidateSet:R-HSA-9959465] Ub-RAC1:GTP,(Ub-CDC42:GTP) [plasma membrane]
regulatedBy	[NegativeRegulation:9959462] Negative regulation by 'Engaged CDH1,(CDH11) [plasma membrane]'
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9958873
summation	[Summation:9959476] Studies with the mouse mammary cell line HC11 showed that...

Referrals

(hasEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement
(precedingEvent)	[BlackBoxEvent:R-HSA-9958874] 26S proteasome degrades ubiquitinated RAC1, CDC42

Cite Us!